Biochemical signaling pathways for memory T cell recall.
Farber, D.L. (2009) Biochemical signaling pathways for memory T cell recall. Sem. Immunol. 21: 84-91. (PDF)
Publications
Costimulation modulation uncouples protection from immunopathology in memory T cell responses to influenza virus.
Teijaro, J.R., Njau, M.P., Verhoeven, D., Chandran, S., Nadler, S.G., Hasday, J, and Farber, D.L. (2009) Costimulation modulation uncouples protection from immunopathology in memory T cell responses to influenza virus. J. Immunol. 182: In Press. (PDF)
Pulse-oximetry accurately predicts lung pathology and the immune response during influenza infection.
Verhoeven, D. and Farber, D.L. (2009) Pulse-oximetry accurately predicts lung pathology and the immune response during influenza infection. Virology. In Press (PDF)
Memory T cell predominance following T cell depletional therapy derives from homeostatic expansion of naive T cells.
Sener, A., Tang, A.L. and Farber, D.L. (submitted) Memory T cell predominance following T cell depletional therapy derives from homeostatic expansion of naive T cells.
TCR signals perpetuate the survival and homeostasis of memory CD4 T cells via cross-regulation with γc cytokine signaling pathways.
Bushar, N.D., Schmidt, M., Maltzman, J., and Farber, D.L. (submitted) TCR signals perpetuate the survival and homeostasis of memory CD4 T cells via cross-regulation with γc cytokine signaling pathways.
Recalling the Year in Memory T cells.
Bushar, N.D. and Farber, D.L. (2008) Recalling the Year in Memory T cells. Annals of the NY Acad. Sci. In Press.
Heterogeneous memory T cells in anti-viral immunity and immunopathology.
Verhoeven, D., Teijaro, J.R., and Farber, D.L. (2008) Heterogeneous memory T cells in anti-viral immunity and immunopathology. Viral Immunology. 21:99-113. (PDF)
A peptide-MHC II chimera favors survival of pancreatic islets grafted in type 1 diabetic mice.
Lin, M., Zhang, N, Teijaro, J. R., Stoica, C., Bona, C., McEvoy, R., Bromberg, J., Farber, D.L., Casares, S., and Brumeanu, T.-D. (2008) A peptide-MHC II chimera favors survival of pancreatic islets grafted in type 1 diabetic mice. Transplantation. 85:1717-1725.
CTLA4 expression is an indicator and regulator of CD4+FoxP3+ T cell homeostasis.
Tang, A.L., Njau, M.N., Teijaro, J.R., Azimzadeh, A., Nadler, S.G. and Farber, D.L. (2008) CTLA4 expression is an indicator and regulator of CD4+FoxP3+ T cell homeostasis. J. Immunol. 181:1806-13. (PDF)
Proximal Signaling control of human CD4 T cell function.
Okoye, F.I., Krishnan, S., Chandok, M.R., Tsokos, G.C., and Farber, D.L. (2007) Proximal Signaling control of human CD4 T cell function. Clin. Immunol. 125:5-15. (PDF)
Generation, homeostasis, and regulation of memory T cells in Transplantation.
Tang, A.L. and Farber, D.L. (2007) Generation, homeostasis, and regulation of memory T cells in Transplantation. Current Opinion in Organ Transplantation. 12:23-29. (PDF)
Reshaping the Past: strategies for modulation of T cell memory.
A biochemical signature for rapid recall by memory CD4 T cells.
Chandok, M.R., Okoye, F.I., Ndejembi, M.P. and Farber, D.L. (2007) A biochemical signature for rapid recall by memory CD4 T cells. J. Immunol. 179:3689-98. (PDF)
Control of Memory CD4 T cell recall by the CD28 costimulatory pathway.
Ndejembi, M.P., Patke, D.S., Bingaman, A.W., Chandok, M.R., Azimzadeh, A., Nadler, S.G., and Farber, D.L. (2006) Control of Memory CD4 T cell recall by the CD28 costimulatory pathway. J. Immunol. 177: 7698-7706. (PDF)
Generation and functional capacity of polyclonal alloantigen-specific memory CD4 T cells.
Tang, A.L., Bingaman, A.W., Kadavil, E.A., Leeser, D.B., and Farber, D.L. (2006) Generation and functional capacity of polyclonal alloantigen-specific memory CD4 T cells. Am. J. Transplant. 6:1275-1284. (PDF) (editorial in the same issue by Fairchild, R., “Developing models to study the memory T cell barrier in transplantation”, 6:1246-7)
Divergentgeneration of heterogeneous memory CD4 T cells.
Moulton, V., Bushar, N., Leeser, D., Patke, D.S. and Farber, D.L. (2006) Divergentgeneration of heterogeneous memory CD4 T cells. J. Immunol. 177: 869-876. (PDF)
Committed to memory: lineage choices for T cells.
Moulton, V. and Farber, D.L. (2006) Committed to memory: lineage choices for T cells.Trends Immunol. 27: 261-67. (PDF)
Human Bone Marrow: a reservoir for enhanced effector-memory CD8 T Cells with potent recall function.
Zhang, X., Dong, H., Lin. W., Voss, S., Hinkley, L., Westergren, M., Berry, D., Lewellen,D., Vile, R. Chen, L., Farber, D.L., and Strome, S.E. (2006) Human Bone Marrow: a reservoir for enhanced effector-memory CD8 T Cells with potent recall function. J. Immunol. 177:6730-7. (PDF)
Modulation of memory CD4 T cell function and survival potential by altering the strength of the recall stimulus.
Patke, D.S. and Farber, D.L. (2005) Modulation of memory CD4 T cell function and survival potential by altering the strength of the recall stimulus. J. Immunol. 174:5433-5443. (PDF)
Novel phenotypes and migration properties distinguish memory CD4 T cell subsets in lymphoid and lung tissue.
Anti-CD3 priming generates heterogeneous antigen-specific memory CD4 T cells.
Patke, D., Ahmadzadeh, M, Bingaman, A.W. and Farber, D.L. (2005) Anti-CD3 priming generates heterogeneous antigen-specific memory CD4 T cells. Clinical Immunology.117:125-32. (PDF) Commentary in same issue by Milone, M.C. and June, C.H.. “Adoptive immunotherapy: new ways to skin the cat?” pp.101-103. (PDF)
Memory T cells in Transplantation: Generation, function and potential role in rejection.
Bingaman, A.W. and Farber, D.L. (2004) Memory T cells in Transplantation: Generation, function and potential role in rejection. Am. J. Transplantation. 4:846-852. (PDF)
Long-term islet graft survival in NOD mice by abrogation of recurrent autoimmunity.
Shi, Q., Wang, D.-W., Hadley, G.A., Bingaman, A.W., Bartlett, S.T, and Farber, D.L. (2004) Long-term islet graft survival in NOD mice by abrogation of recurrent autoimmunity. Diabetes. 53:2338-45. (PDF)
Signaling Control of Memory T cell generation and function.
Chandok, M. and Farber, D.L. (2004) Signaling Control of Memory T cell generation and function. Seminars in Immunology. 16:285-93. (PDF)
The FcRγ subunit and Syk kinase replace CD3 and ZAP-70 in the TCR/CD3 signaling complex of human effector CD4 T cells.
Krishnan, S., Warke, V, Nambiar, M.P., Tsokos, G.C., and Farber, D.L. (2003) The FcRγ subunit and Syk kinase replace CD3 and ZAP-70 in the TCR/CD3 signaling complex of human effector CD4 T cells. J. Immunol. 170: 4189-4195.
T cell rewiring in differentiation and disease.
Krishnan, S., Farber, D.L., and Tsokos, G.C. (2003) T cell rewiring in differentiation and disease. J. Immunol. 171: 3325-3331.
Gene transfection and expression in resting and activated subsets of murine CD4 T cells.
Lai, W., Chang, C.-H., and Farber, D.L. (2003) Gene transfection and expression in resting and activated subsets of murine CD4 T cells. J. Immunol. Meth. 282: 93-102.
Differential SLP-76 expression and TCR-mediated signaling in effector and memory CD4 T cells.
Hussain, S.F., Anderson, C.A. and Farber, D.L. (2002) Differential SLP-76 expression and TCR-mediated signaling in effector and memory CD4 T cells. J. Immunol. 168:1557-1565.
Functional Plasticity of an antigen-specific memory CD4 T cell population.
Ahmadzadeh, M. and Farber, D.L. (2002) Functional Plasticity of an antigen-specific memory CD4 T cell population. Proc. Natl’l Acad. Sci, U.S.A. 99:11802-11807.
CD103 expression is required for destruction of pancreatic islet allografts by CD8 T cells.
Feng, Y., Wang, D, Yuan, R., Farber, D.L. and Hadley, G.A. (2002). CD103 expression is required for destruction of pancreatic islet allografts by CD8 T cells. J. Exp. Med. 196:877-886. Commentary in J. Exp. Med. 196:873-875.
Heterogeneity of the memory CD4 T cell response: persisting effectors and resting memory T cells.
Ahmazadeh, M., Hussain, S.F. and Farber, D.L. (2001) Heterogeneity of the memory CD4 T cell response: persisting effectors and resting memory T cells. J. Immunol. 166:926-935.
Generation and Biochemical Analysis of human effector CD4 T cells: alterations in tyrosine phosphorylation and loss of CD3ζ expression.
Krishnan, S., Warke, V., Wong, H., Nambiar, M., Tsokos, G., and Farber, D.L. (2001) Generation and Biochemical Analysis of human effector CD4 T cells: alterations in tyrosine phosphorylation and loss of CD3ζ expression. Blood. 97:3851-59.